
RSVA 405
CAS No. 140405-36-3
RSVA 405( —— )
Catalog No. M22013 CAS No. 140405-36-3
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 80 | Get Quote |
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10MG | 132 | Get Quote |
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25MG | 295 | Get Quote |
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50MG | 514 | Get Quote |
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100MG | 737 | Get Quote |
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500MG | 1521 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameRSVA 405
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NoteResearch use only, not for human use.
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Brief DescriptionRSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.
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DescriptionRSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.
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In VitroRSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation.RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells.RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages.RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC50 of ~1 μM in APP-HEK293 cells.Cell Viability Assay Cell Line:3T3-L1 preadipocytes Concentration:0.2, 0.5, 1, 2 μM Incubation Time:24 h Result:Increased the phosphorylation of AMPK and its substrate acetyl-CoA carboxylase (ACC).Inhibited the accumulation of lipid droplets in a dose-dependent manner, with an IC50 of 0.5 μM.
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In VivoRSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats.RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet. Animal Model:Male Sprague-Dawley rats (300-350 g) are induced I/R injury Dosage:3 mg/kg Administration:I.p. one hour before inducing I/R injury Result:Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT3|AMPK
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Research Area——
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Indication——
Chemical Information
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CAS Number140405-36-3
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Formula Weight312.37
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Molecular FormulaC17H20N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (400.17 mM)
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SMILESCCN(CC)C1=CC(O)=C(C=NNC(=O)C2=CC=NC=C2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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