RSVA 405

CAS No. 140405-36-3

RSVA 405( —— )

Catalog No. M22013 CAS No. 140405-36-3

RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RSVA 405
  • Note
    Research use only, not for human use.
  • Brief Description
    RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.
  • Description
    RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor.
  • In Vitro
    RSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation.RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells.RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages.RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC50 of ~1 μM in APP-HEK293 cells.Cell Viability Assay Cell Line:3T3-L1 preadipocytes Concentration:0.2, 0.5, 1, 2 μM Incubation Time:24 h Result:Increased the phosphorylation of AMPK and its substrate acetyl-CoA carboxylase (ACC).Inhibited the accumulation of lipid droplets in a dose-dependent manner, with an IC50 of 0.5 μM.
  • In Vivo
    RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats.RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet. Animal Model:Male Sprague-Dawley rats (300-350 g) are induced I/R injury Dosage:3 mg/kg Administration:I.p. one hour before inducing I/R injury Result:Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT3|AMPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    140405-36-3
  • Formula Weight
    312.37
  • Molecular Formula
    C17H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (400.17 mM)
  • SMILES
    CCN(CC)C1=CC(O)=C(C=NNC(=O)C2=CC=NC=C2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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